diff --git a/src/shader_recompiler/backend/spirv/emit_spirv_context_get_set.cpp b/src/shader_recompiler/backend/spirv/emit_spirv_context_get_set.cpp
index fb9d3dbbb2..f4d9de79d3 100644
--- a/src/shader_recompiler/backend/spirv/emit_spirv_context_get_set.cpp
+++ b/src/shader_recompiler/backend/spirv/emit_spirv_context_get_set.cpp
@@ -202,7 +202,8 @@ void EmitGetIndirectBranchVariable(EmitContext&) {
 }
 
 Id EmitGetCbufU8(EmitContext& ctx, const IR::Value& binding, const IR::Value& offset) {
-    if (ctx.profile.support_descriptor_aliasing && ctx.profile.support_int8) {
+    if (ctx.profile.support_descriptor_aliasing && ctx.profile.support_int8 &&
+        ctx.profile.support_uniform_and_storage_buffer_8bit) {
         const Id load{GetCbuf(ctx, ctx.U8, &UniformDefinitions::U8, sizeof(u8), binding, offset,
                               ctx.load_const_func_u8)};
         return ctx.OpUConvert(ctx.U32[1], load);
@@ -219,7 +220,8 @@ Id EmitGetCbufU8(EmitContext& ctx, const IR::Value& binding, const IR::Value& of
 }
 
 Id EmitGetCbufS8(EmitContext& ctx, const IR::Value& binding, const IR::Value& offset) {
-    if (ctx.profile.support_descriptor_aliasing && ctx.profile.support_int8) {
+    if (ctx.profile.support_descriptor_aliasing && ctx.profile.support_int8 &&
+        ctx.profile.support_uniform_and_storage_buffer_8bit) {
         const Id load{GetCbuf(ctx, ctx.S8, &UniformDefinitions::S8, sizeof(s8), binding, offset,
                               ctx.load_const_func_u8)};
         return ctx.OpSConvert(ctx.U32[1], load);
@@ -236,7 +238,8 @@ Id EmitGetCbufS8(EmitContext& ctx, const IR::Value& binding, const IR::Value& of
 }
 
 Id EmitGetCbufU16(EmitContext& ctx, const IR::Value& binding, const IR::Value& offset) {
-    if (ctx.profile.support_descriptor_aliasing && ctx.profile.support_int16) {
+    if (ctx.profile.support_descriptor_aliasing && ctx.profile.support_int16 &&
+        ctx.profile.support_uniform_and_storage_buffer_16bit) {
         const Id load{GetCbuf(ctx, ctx.U16, &UniformDefinitions::U16, sizeof(u16), binding, offset,
                               ctx.load_const_func_u16)};
         return ctx.OpUConvert(ctx.U32[1], load);
@@ -253,7 +256,8 @@ Id EmitGetCbufU16(EmitContext& ctx, const IR::Value& binding, const IR::Value& o
 }
 
 Id EmitGetCbufS16(EmitContext& ctx, const IR::Value& binding, const IR::Value& offset) {
-    if (ctx.profile.support_descriptor_aliasing && ctx.profile.support_int16) {
+    if (ctx.profile.support_descriptor_aliasing && ctx.profile.support_int16 &&
+        ctx.profile.support_uniform_and_storage_buffer_16bit) {
         const Id load{GetCbuf(ctx, ctx.S16, &UniformDefinitions::S16, sizeof(s16), binding, offset,
                               ctx.load_const_func_u16)};
         return ctx.OpSConvert(ctx.U32[1], load);
diff --git a/src/shader_recompiler/backend/spirv/spirv_emit_context.cpp b/src/shader_recompiler/backend/spirv/spirv_emit_context.cpp
index c5c6b2655a..b1bed263a6 100644
--- a/src/shader_recompiler/backend/spirv/spirv_emit_context.cpp
+++ b/src/shader_recompiler/backend/spirv/spirv_emit_context.cpp
@@ -1134,7 +1134,7 @@ void EmitContext::DefineConstantBuffers(const Info& info, u32& binding) {
         }
     }
     if (True(types & IR::Type::U16)) {
-        if (profile.support_int16) {
+        if (profile.support_int16 && profile.support_uniform_and_storage_buffer_16bit) {
             DefineConstBuffers(*this, info, &UniformDefinitions::U16, binding, U16, 'u',
                                sizeof(u16));
             DefineConstBuffers(*this, info, &UniformDefinitions::S16, binding, S16, 's',
@@ -1196,10 +1196,18 @@ void EmitContext::DefineConstantBufferIndirectFunctions(const Info& info) {
     IR::Type types{info.used_indirect_cbuf_types};
     bool supports_aliasing = profile.support_descriptor_aliasing;
     if (supports_aliasing && True(types & IR::Type::U8)) {
-        load_const_func_u8 = make_accessor(U8, &UniformDefinitions::U8);
+        if (profile.support_int8 && profile.support_uniform_and_storage_buffer_8bit) {
+            load_const_func_u8 = make_accessor(U8, &UniformDefinitions::U8);
+        } else {
+            types |= IR::Type::U32;
+        }
     }
     if (supports_aliasing && True(types & IR::Type::U16)) {
-        load_const_func_u16 = make_accessor(U16, &UniformDefinitions::U16);
+        if (profile.support_int16 && profile.support_uniform_and_storage_buffer_16bit) {
+            load_const_func_u16 = make_accessor(U16, &UniformDefinitions::U16);
+        } else {
+            types |= IR::Type::U32;
+        }
     }
     if (supports_aliasing && True(types & IR::Type::F32)) {
         load_const_func_f32 = make_accessor(F32[1], &UniformDefinitions::F32);
diff --git a/src/shader_recompiler/profile.h b/src/shader_recompiler/profile.h
index 4e200d5120..e95778a0de 100644
--- a/src/shader_recompiler/profile.h
+++ b/src/shader_recompiler/profile.h
@@ -17,6 +17,7 @@ struct Profile {
     bool support_int8{};
     bool support_uniform_and_storage_buffer_8bit{};
     bool support_int16{};
+    bool support_uniform_and_storage_buffer_16bit{};
     bool support_int64{};
     bool support_vertex_instance_id{};
     bool support_float_controls{};
diff --git a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
index 74caf044cb..903b97db6a 100644
--- a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
+++ b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
@@ -386,6 +386,8 @@ PipelineCache::PipelineCache(Tegra::MaxwellDeviceMemoryManager& device_memory_,
         .support_uniform_and_storage_buffer_8bit =
             device.IsUniformAndStorageBuffer8BitAccessSupported(),
         .support_int16 = device.IsShaderInt16Supported(),
+        .support_uniform_and_storage_buffer_16bit =
+            device.IsUniformAndStorageBuffer16BitAccessSupported(),
         .support_int64 = device.IsShaderInt64Supported(),
         .support_vertex_instance_id = false,
         .support_float_controls = device.IsKhrShaderFloatControlsSupported(),
diff --git a/src/video_core/vulkan_common/vulkan_device.h b/src/video_core/vulkan_common/vulkan_device.h
index 457cd3286e..5b6c3da57d 100644
--- a/src/video_core/vulkan_common/vulkan_device.h
+++ b/src/video_core/vulkan_common/vulkan_device.h
@@ -387,11 +387,16 @@ FN_MAX_LIMIT_LIST
         return features.shader_float16_int8.shaderInt8;
     }
 
-    /// Returns true if the device allows 8-bit integer members
+    /// Returns true if the device allows 8-bit integer members in uniform/storage buffers.
     bool IsUniformAndStorageBuffer8BitAccessSupported() const {
         return features.bit8_storage.uniformAndStorageBuffer8BitAccess;
     }
 
+    /// Returns true if the device allows 16-bit integer members in uniform/storage buffers.
+    bool IsUniformAndStorageBuffer16BitAccessSupported() const {
+        return features.bit16_storage.uniformAndStorageBuffer16BitAccess;
+    }
+
     /// Returns true if the device supports binding multisample images as storage images.
     bool IsStorageImageMultisampleSupported() const {
         return features.features.shaderStorageImageMultisample;