diff --git a/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp b/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
index 6301b1aae4..a9a9529f30 100644
--- a/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
+++ b/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
@@ -263,6 +263,7 @@ GraphicsPipeline::GraphicsPipeline(
         std::ranges::copy(info->constant_buffer_used_sizes, uniform_buffer_sizes[stage].begin());
         num_textures += Shader::NumDescriptors(info->texture_descriptors);
     }
+    fragment_has_color0_output = stage_infos[NUM_STAGES - 1].stores_frag_color[0];
     auto func{[this, shader_notify, &render_pass_cache, &descriptor_pool, pipeline_statistics] {
         DescriptorLayoutBuilder builder{MakeBuilder(device, stage_infos)};
         uses_push_descriptor = builder.CanUsePushDescriptor();
@@ -739,6 +740,7 @@ void GraphicsPipeline::MakePipeline(VkRenderPass render_pass) {
         provoking_vertex.pNext = std::exchange(rasterization_ci.pNext, &provoking_vertex);
     }
 
+    const bool supports_alpha_output = fragment_has_color0_output;
     const VkPipelineMultisampleStateCreateInfo multisample_ci{
         .sType = VK_STRUCTURE_TYPE_PIPELINE_MULTISAMPLE_STATE_CREATE_INFO,
         .pNext = nullptr,
@@ -747,8 +749,10 @@ void GraphicsPipeline::MakePipeline(VkRenderPass render_pass) {
         .sampleShadingEnable = Settings::values.sample_shading.GetValue() ? VK_TRUE : VK_FALSE,
         .minSampleShading = static_cast<float>(Settings::values.sample_shading_fraction.GetValue()) / 100.0f,
         .pSampleMask = nullptr,
-        .alphaToCoverageEnable = key.state.alpha_to_coverage_enabled != 0 ? VK_TRUE : VK_FALSE,
-        .alphaToOneEnable = key.state.alpha_to_one_enabled != 0 ? VK_TRUE : VK_FALSE,
+        .alphaToCoverageEnable =
+            supports_alpha_output && key.state.alpha_to_coverage_enabled != 0 ? VK_TRUE : VK_FALSE,
+        .alphaToOneEnable =
+            supports_alpha_output && key.state.alpha_to_one_enabled != 0 ? VK_TRUE : VK_FALSE,
     };
     const VkPipelineDepthStencilStateCreateInfo depth_stencil_ci{
         .sType = VK_STRUCTURE_TYPE_PIPELINE_DEPTH_STENCIL_STATE_CREATE_INFO,
diff --git a/src/video_core/renderer_vulkan/vk_graphics_pipeline.h b/src/video_core/renderer_vulkan/vk_graphics_pipeline.h
index c8e89d60a4..80f44643e2 100644
--- a/src/video_core/renderer_vulkan/vk_graphics_pipeline.h
+++ b/src/video_core/renderer_vulkan/vk_graphics_pipeline.h
@@ -82,6 +82,13 @@ public:
         const std::array<const Shader::Info*, NUM_STAGES>& infos);
 
     bool HasDynamicVertexInput() const noexcept { return key.state.dynamic_vertex_input; }
+    bool SupportsAlphaToCoverage() const noexcept {
+        return fragment_has_color0_output;
+    }
+
+    bool SupportsAlphaToOne() const noexcept {
+        return fragment_has_color0_output;
+    }
     GraphicsPipeline& operator=(GraphicsPipeline&&) noexcept = delete;
     GraphicsPipeline(GraphicsPipeline&&) noexcept = delete;
 
@@ -149,6 +156,7 @@ private:
     std::array<u32, 5> enabled_uniform_buffer_masks{};
     VideoCommon::UniformBufferSizes uniform_buffer_sizes{};
     u32 num_textures{};
+    bool fragment_has_color0_output{};
 
     vk::DescriptorSetLayout descriptor_set_layout;
     DescriptorAllocator descriptor_allocator;
diff --git a/src/video_core/renderer_vulkan/vk_rasterizer.cpp b/src/video_core/renderer_vulkan/vk_rasterizer.cpp
index 1891983bbc..a12382fc05 100644
--- a/src/video_core/renderer_vulkan/vk_rasterizer.cpp
+++ b/src/video_core/renderer_vulkan/vk_rasterizer.cpp
@@ -1443,9 +1443,11 @@ void RasterizerVulkan::UpdateAlphaToCoverageEnable(Tegra::Engines::Maxwell3D::Re
     if (!state_tracker.TouchAlphaToCoverageEnable()) {
         return;
     }
-    scheduler.Record([enable = regs.anti_alias_alpha_control.alpha_to_coverage](
-                         vk::CommandBuffer cmdbuf) {
-        cmdbuf.SetAlphaToCoverageEnableEXT(enable != 0);
+    GraphicsPipeline* const pipeline = pipeline_cache.CurrentGraphicsPipeline();
+    const bool enable = pipeline != nullptr && pipeline->SupportsAlphaToCoverage() &&
+                        regs.anti_alias_alpha_control.alpha_to_coverage != 0;
+    scheduler.Record([enable](vk::CommandBuffer cmdbuf) {
+        cmdbuf.SetAlphaToCoverageEnableEXT(enable ? VK_TRUE : VK_FALSE);
     });
 }
 
@@ -1453,9 +1455,11 @@ void RasterizerVulkan::UpdateAlphaToOneEnable(Tegra::Engines::Maxwell3D::Regs& r
     if (!state_tracker.TouchAlphaToOneEnable()) {
         return;
     }
-    scheduler.Record([enable = regs.anti_alias_alpha_control.alpha_to_one](
-                         vk::CommandBuffer cmdbuf) {
-        cmdbuf.SetAlphaToOneEnableEXT(enable != 0);
+    GraphicsPipeline* const pipeline = pipeline_cache.CurrentGraphicsPipeline();
+    const bool enable = pipeline != nullptr && pipeline->SupportsAlphaToOne() &&
+                        regs.anti_alias_alpha_control.alpha_to_one != 0;
+    scheduler.Record([enable](vk::CommandBuffer cmdbuf) {
+        cmdbuf.SetAlphaToOneEnableEXT(enable ? VK_TRUE : VK_FALSE);
     });
 }