diff --git a/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp b/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
index dca263b322..d89a992281 100644
--- a/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
+++ b/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
@@ -862,6 +862,9 @@ void GraphicsPipeline::MakePipeline(VkRenderPass render_pass) {
     const bool alpha_to_one_supported = device.SupportsAlphaToOne();
     const auto msaa_mode = key.state.msaa_mode.Value();
     const VkSampleCountFlagBits vk_samples = MaxwellToVK::MsaaMode(msaa_mode);
+    const bool supports_sample_locations =
+        device.IsExtSampleLocationsSupported() && device.SupportsSampleLocationsFor(vk_samples);
+
     VkPipelineMultisampleStateCreateInfo multisample_ci{
         .sType = VK_STRUCTURE_TYPE_PIPELINE_MULTISAMPLE_STATE_CREATE_INFO,
         .pNext = nullptr,
@@ -876,6 +879,37 @@ void GraphicsPipeline::MakePipeline(VkRenderPass render_pass) {
                            key.state.alpha_to_one_enabled != 0 ? VK_TRUE : VK_FALSE,
     };
 
+    struct SampleLocationsChain {
+        std::array<VkSampleLocationEXT, VideoCommon::MaxSampleLocationSlots> locations;
+        VkSampleLocationsInfoEXT info;
+        VkPipelineSampleLocationsStateCreateInfoEXT create;
+    };
+    std::optional<SampleLocationsChain> sample_locations_chain;
+    if (supports_sample_locations) {
+        sample_locations_chain.emplace();
+        auto& chain = *sample_locations_chain;
+        const auto [grid_width, grid_height] = VideoCommon::SampleLocationGridSize(msaa_mode);
+        const u32 samples_per_pixel = static_cast<u32>(VideoCommon::NumSamples(msaa_mode));
+        const u32 sample_locations_count = grid_width * grid_height * samples_per_pixel;
+        chain.locations.fill(VkSampleLocationEXT{0.5f, 0.5f});
+        chain.info = VkSampleLocationsInfoEXT{
+            .sType = VK_STRUCTURE_TYPE_SAMPLE_LOCATIONS_INFO_EXT,
+            .pNext = nullptr,
+            .sampleLocationsPerPixel = vk_samples,
+            .sampleLocationGridSize = VkExtent2D{grid_width, grid_height},
+            .sampleLocationsCount = sample_locations_count,
+            .pSampleLocations = chain.locations.data(),
+        };
+        chain.create = VkPipelineSampleLocationsStateCreateInfoEXT{
+            .sType = VK_STRUCTURE_TYPE_PIPELINE_SAMPLE_LOCATIONS_STATE_CREATE_INFO_EXT,
+            .pNext = nullptr,
+            .sampleLocationsEnable = VK_TRUE,
+            .sampleLocationsInfo = chain.info,
+        };
+        chain.create.sampleLocationsInfo.pSampleLocations = chain.locations.data();
+        chain.create.pNext = std::exchange(multisample_ci.pNext, &chain.create);
+    }
+
     const VkPipelineDepthStencilStateCreateInfo depth_stencil_ci{
         .sType = VK_STRUCTURE_TYPE_PIPELINE_DEPTH_STENCIL_STATE_CREATE_INFO,
         .pNext = nullptr,
@@ -961,6 +995,10 @@ void GraphicsPipeline::MakePipeline(VkRenderPass render_pass) {
         VK_DYNAMIC_STATE_LINE_WIDTH,
     };
 
+    if (supports_sample_locations) {
+        dynamic_states.push_back(VK_DYNAMIC_STATE_SAMPLE_LOCATIONS_EXT);
+    }
+
     if (device.UsesAdvancedCoreDynamicState()) {
         static constexpr std::array core_dynamic_states{
             VK_DYNAMIC_STATE_BLEND_CONSTANTS,
diff --git a/src/video_core/renderer_vulkan/vk_rasterizer.cpp b/src/video_core/renderer_vulkan/vk_rasterizer.cpp
index 1ebb36f707..91fc570cda 100644
--- a/src/video_core/renderer_vulkan/vk_rasterizer.cpp
+++ b/src/video_core/renderer_vulkan/vk_rasterizer.cpp
@@ -51,6 +51,24 @@ using VideoCommon::ImageViewType;
 
 
 namespace {
+constexpr float SAMPLE_LOCATION_SCALE = 1.0f / 16.0f;
+
+std::array<VkSampleLocationEXT, VideoCommon::MaxSampleLocationSlots>
+DecodeSampleLocationRegisters(const Maxwell& regs) {
+    std::array<VkSampleLocationEXT, VideoCommon::MaxSampleLocationSlots> decoded{};
+    size_t index = 0;
+    for (const auto& packed : regs.multisample_sample_locations) {
+        for (int slot = 0; slot < 4 && index < decoded.size(); ++slot, ++index) {
+            const auto [raw_x, raw_y] = packed.Location(slot);
+            decoded[index] = VkSampleLocationEXT{
+                .x = static_cast<float>(raw_x) * SAMPLE_LOCATION_SCALE,
+                .y = static_cast<float>(raw_y) * SAMPLE_LOCATION_SCALE,
+            };
+        }
+    }
+    return decoded;
+}
+
 struct DrawParams {
     u32 base_instance;
     u32 num_instances;
@@ -1015,6 +1033,7 @@ void RasterizerVulkan::UpdateDynamicStates() {
     UpdateDepthBounds(regs);
     UpdateStencilFaces(regs);
     UpdateLineWidth(regs);
+    UpdateSampleLocations(regs);
     
     // EDS1: CullMode, DepthCompare, FrontFace, StencilOp, DepthBoundsTest, DepthTest, DepthWrite, StencilTest
     if (device.IsExtExtendedDynamicStateSupported()) {
@@ -1663,6 +1682,79 @@ void RasterizerVulkan::UpdateStencilOp(Tegra::Engines::Maxwell3D::Regs& regs) {
     }
 }
 
+void RasterizerVulkan::UpdateSampleLocations(Maxwell::Regs& regs) {
+    if (!device.IsExtSampleLocationsSupported()) {
+        return;
+    }
+
+    const auto msaa_mode = regs.anti_alias_samples_mode;
+    const VkSampleCountFlagBits vk_samples = MaxwellToVK::MsaaMode(msaa_mode);
+    if (!device.SupportsSampleLocationsFor(vk_samples)) {
+        return;
+    }
+
+    const auto [grid_width_u32, grid_height_u32] = VideoCommon::SampleLocationGridSize(msaa_mode);
+    const u32 grid_width = grid_width_u32;
+    const u32 grid_height = grid_height_u32;
+    const u32 samples_per_pixel = static_cast<u32>(VideoCommon::NumSamples(msaa_mode));
+    const u32 grid_cells = grid_width * grid_height;
+    const u32 sample_locations_count = grid_cells * samples_per_pixel;
+    ASSERT(sample_locations_count <= VideoCommon::MaxSampleLocationSlots);
+
+    const auto raw_locations = DecodeSampleLocationRegisters(regs);
+    std::array<VkSampleLocationEXT, VideoCommon::MaxSampleLocationSlots> resolved{};
+    for (u32 cell = 0; cell < grid_cells; ++cell) {
+        const u32 slot_base = cell * samples_per_pixel;
+        const u32 cell_x = cell % grid_width;
+        const u32 cell_y = cell / grid_width;
+        for (u32 sample = 0; sample < samples_per_pixel; ++sample) {
+            const VkSampleLocationEXT raw = raw_locations[slot_base + sample];
+            resolved[slot_base + sample] = VkSampleLocationEXT{
+                .x = static_cast<float>(cell_x) + raw.x,
+                .y = static_cast<float>(cell_y) + raw.y,
+            };
+        }
+    }
+
+    const VkExtent2D grid_size{
+        .width = grid_width,
+        .height = grid_height,
+    };
+
+    const bool pattern_changed = !sample_location_state.initialized ||
+                                 sample_location_state.msaa_mode != msaa_mode ||
+                                 sample_location_state.grid_size.width != grid_size.width ||
+                                 sample_location_state.grid_size.height != grid_size.height ||
+                                 sample_location_state.samples_per_pixel != vk_samples ||
+                                 sample_location_state.locations_count != sample_locations_count ||
+                                 sample_location_state.locations != resolved;
+
+    const bool dirty = state_tracker.TouchSampleLocations() || pattern_changed;
+    if (!dirty) {
+        return;
+    }
+
+    scheduler.Record([resolved, grid_size, vk_samples, sample_locations_count](
+                         vk::CommandBuffer cmdbuf) {
+        VkSampleLocationsInfoEXT info{
+            .sType = VK_STRUCTURE_TYPE_SAMPLE_LOCATIONS_INFO_EXT,
+            .pNext = nullptr,
+            .sampleLocationsPerPixel = vk_samples,
+            .sampleLocationGridSize = grid_size,
+            .sampleLocationsCount = sample_locations_count,
+            .pSampleLocations = resolved.data(),
+        };
+        cmdbuf.SetSampleLocationsEXT(info);
+    });
+
+    sample_location_state.msaa_mode = msaa_mode;
+    sample_location_state.grid_size = grid_size;
+    sample_location_state.samples_per_pixel = vk_samples;
+    sample_location_state.locations_count = sample_locations_count;
+    sample_location_state.locations = resolved;
+    sample_location_state.initialized = true;
+}
+
 void RasterizerVulkan::UpdateLogicOp(Tegra::Engines::Maxwell3D::Regs& regs) {
     if (!state_tracker.TouchLogicOp()) {
         return;
diff --git a/src/video_core/renderer_vulkan/vk_rasterizer.h b/src/video_core/renderer_vulkan/vk_rasterizer.h
index b689c6b660..9c9809c0da 100644
--- a/src/video_core/renderer_vulkan/vk_rasterizer.h
+++ b/src/video_core/renderer_vulkan/vk_rasterizer.h
@@ -25,6 +25,7 @@
 #include "video_core/renderer_vulkan/vk_staging_buffer_pool.h"
 #include "video_core/renderer_vulkan/vk_texture_cache.h"
 #include "video_core/renderer_vulkan/vk_update_descriptor.h"
+#include "video_core/texture_cache/samples_helper.h"
 #include "video_core/vulkan_common/vulkan_memory_allocator.h"
 #include "video_core/vulkan_common/vulkan_wrapper.h"
 
@@ -168,6 +169,7 @@ private:
     void UpdateDepthBounds(Tegra::Engines::Maxwell3D::Regs& regs);
     void UpdateStencilFaces(Tegra::Engines::Maxwell3D::Regs& regs);
     void UpdateLineWidth(Tegra::Engines::Maxwell3D::Regs& regs);
+    void UpdateSampleLocations(Tegra::Engines::Maxwell3D::Regs& regs);
 
     void UpdateCullMode(Tegra::Engines::Maxwell3D::Regs& regs);
     void UpdateDepthBoundsTestEnable(Tegra::Engines::Maxwell3D::Regs& regs);
@@ -193,6 +195,17 @@ private:
 
     void UpdateVertexInput(Tegra::Engines::Maxwell3D::Regs& regs);
 
+    struct SampleLocationState {
+        Tegra::Texture::MsaaMode msaa_mode{Tegra::Texture::MsaaMode::Msaa1x1};
+        VkExtent2D grid_size{1u, 1u};
+        VkSampleCountFlagBits samples_per_pixel{VK_SAMPLE_COUNT_1_BIT};
+        u32 locations_count{VideoCommon::MaxSampleLocationSlots};
+        std::array<VkSampleLocationEXT, VideoCommon::MaxSampleLocationSlots> locations{};
+        bool initialized = false;
+    };
+
+    SampleLocationState sample_location_state{};
+
     Tegra::GPU& gpu;
     Tegra::MaxwellDeviceMemoryManager& device_memory;
 
diff --git a/src/video_core/renderer_vulkan/vk_state_tracker.cpp b/src/video_core/renderer_vulkan/vk_state_tracker.cpp
index 79967d540a..1610827598 100644
--- a/src/video_core/renderer_vulkan/vk_state_tracker.cpp
+++ b/src/video_core/renderer_vulkan/vk_state_tracker.cpp
@@ -40,6 +40,7 @@ Flags MakeInvalidationFlags() {
         StencilWriteMask,
         StencilCompare,
         LineWidth,
+        SampleLocations,
         CullMode,
         DepthBoundsEnable,
         DepthTestEnable,
@@ -129,6 +130,12 @@ void SetupDirtyLineWidth(Tables& tables) {
     tables[0][OFF(line_width_aliased)] = LineWidth;
 }
 
+void SetupDirtySampleLocations(Tables& tables) {
+    FillBlock(tables[0], OFF(multisample_sample_locations),
+              NUM(multisample_sample_locations), SampleLocations);
+    tables[0][OFF(anti_alias_samples_mode)] = SampleLocations;
+}
+
 void SetupDirtyCullMode(Tables& tables) {
     auto& table = tables[0];
     table[OFF(gl_cull_face)] = CullMode;
@@ -246,6 +253,7 @@ void StateTracker::SetupTables(Tegra::Control::ChannelState& channel_state) {
     SetupDirtyDepthBounds(tables);
     SetupDirtyStencilProperties(tables);
     SetupDirtyLineWidth(tables);
+    SetupDirtySampleLocations(tables);
     SetupDirtyCullMode(tables);
     SetupDirtyStateEnable(tables);
     SetupDirtyDepthCompareOp(tables);
diff --git a/src/video_core/renderer_vulkan/vk_state_tracker.h b/src/video_core/renderer_vulkan/vk_state_tracker.h
index 74bae9e181..e1c54eb3fc 100644
--- a/src/video_core/renderer_vulkan/vk_state_tracker.h
+++ b/src/video_core/renderer_vulkan/vk_state_tracker.h
@@ -42,6 +42,7 @@ enum : u8 {
     StencilWriteMask,
     StencilCompare,
     LineWidth,
+    SampleLocations,
 
     CullMode,
     DepthBoundsEnable,
@@ -185,6 +186,10 @@ public:
         return Exchange(Dirty::LineWidth, false);
     }
 
+    bool TouchSampleLocations() const {
+        return Exchange(Dirty::SampleLocations, false);
+    }
+
     bool TouchCullMode() {
         return Exchange(Dirty::CullMode, false);
     }